Terbin 1% Cream

Uses of

• Treats fungal skin infections

How does Terbin 1% Cream work?

Terbinafine destroys fungal cell membranes that are essential for their survival as they prevent the entry of unwanted substances into the cells and stop the leakage of cell contents. Thereby, kills fungi and clears infection. 

Side Effects of Terbin 1% Cream

• Skin itching
• Skin peeling
• Change in skin color
• Skin redness at the site of application
• Dry skin
• Burning sensation at the application site

Quick Suggestions:

• Terbinafine helps treat fungal infections of the skin and nails.
• Do not skip any doses and finish the full course of treatment even if you feel better.
• Treatment may be needed for 2 to 6 weeks for skin infections and 6 weeks to 6 months for nail infections.
• It can make your skin more sensitive to the sun. Use broad-spectrum sunscreen and protective clothing when outdoors.
• Your doctor may monitor your liver function regularly during treatment. Inform your doctor if you notice yellowing of eyes or skin, dark urine, or stomach pain.
• Inform your doctor if you are pregnant, planning to conceive or breastfeeding.

Indication of Terbin 1% Cream

Terbinafine is an antifungal medication. It kills and stops the growth of the fungi by destroying their cell membrane, thereby treating your skin infection.

Pharmacology

Terbinafine is an Allylamine antifungal that inhibits the biosynthesis of Ergosterol, a crucial component of the fungal cell membrane, by blocking the Squalene Epoxidase enzyme. This leads to increased membrane permeability due to the accumulation of high concentrations of Squalene, resulting in fungal cell death primarily because of membrane disruption rather than Ergosterol deficiency. Depending on the drug concentration and the fungal species tested in vitro, Terbinafine hydrochloride may exhibit fungicidal activity. However, the clinical significance of in vitro data is uncertain. Terbinafine has been shown to be active against most strains of Trichophyton mentagrophytes and Trichophyton rubrum, both in vitro and in clinical infections.

Dosage & Administration of Terbin 1% Cream

Terbinafine cream can be applied once or twice daily. Before application, cleanse and dry the affected areas thoroughly. Apply a thin layer of the cream to the affected skin and surrounding area and lightly rub it in. For intertriginous infections (submammary, interdigital, intergluteal, inguinal), the application may be covered with a gauze strip, especially at night. The typical durations of treatment for various conditions are as follows:

• Tinea corporis, cruris: 1 to 2 weeks
• Tinea pedis: 1 week
• Cutaneous candidiasis: 2 weeks
• Pityriasis Versicolor: 2 weeks

Relief of clinical symptoms usually occurs within a few days. It is crucial to use the cream regularly and complete the treatment to avoid recurrence. If there are no signs of improvement after two weeks, the diagnosis should be verified.

Interaction

Terbinafine may interact with various drugs, including those used to treat stomach ulcers, antibiotics, antifungal medications, high blood pressure medications, antidepressants, opioid painkillers, blood thinners, heart-related medicines, and immunosuppressants. It may also interact with caffeine-containing foods and drinks, such as chocolate, tea, coffee, cola, and energy drinks, leading to increased adverse effects of caffeine.

For individuals with certain health conditions like lupus, weakened immune system, and kidney or liver problems, it is essential to inform their doctor before taking Terbinafine to ensure safe and appropriate use.

Contraindications

Terbinafine Cream is contraindicated in individuals hypersensitive to terbinafine.

Pregnancy & Lactation

Animal studies suggest no adverse effects on the fetus and fertility. However, there is no clinical experience with terbinafine in pregnant women. Unless the potential benefits outweigh any potential risks, terbinafine should not be administered during pregnancy. Terbinafine is excreted in breast milk, so mothers should not use terbinafine cream while breastfeeding.

Precautions & Warnings

• Avoid taking Terbinafine if you are allergic to terbinafine.
• If you are pregnant or a nursing mother, consult a doctor before using Terbinafine.
• Limit sun exposure while using Terbinafine, as it may make the skin more sensitive to sunlight. Wear protective clothing and use sunscreen to prevent sunburn.
• Inform your doctor if you have lupus, a weakened immune system, or kidney or liver problems before taking Terbinafine.
• If you experience depressive symptoms, such as feeling worthless or sad, loss of interest or energy in daily activities, mood changes, restlessness, or changes in sleep patterns, inform your doctor immediately.

Storage Conditions

Protect from light and moisture by storing below 30°C. Keep the medicine out of children's reach.